Musical of 'Rocky' heading to Broadway

NEW YORK (AP) ? It's been a knockout in Germany. Now Sylvester Stallone hopes a musical based on his beloved boxing film "Rocky" will also be a hit on Broadway.

Producers said Sunday they plan to get "Rocky" up and punching at the Winter Garden by February following a successful debut in Hamburg last fall.

Based on the Oscar-winning 1976 film, the musical features a score by "Ragtime" veterans Stephen Flaherty and Lynn Ahrens, and a story by Thomas Meehan, who wrote "The Producers" and "Hairspray."

Originally written in English but translated into German for its world premiere and billed as "Rocky: Das Musical," the show is produced by Stallone and Stage Entertainment USA.

"The reason I think it has worked so well there and why I think it'll work on Broadway is that, yes, it's a story about boxing, but the real story is actually an intimate, powerful and gritty and moving love story between two people who are both lonely and in a difficult place in their worlds," said Bill Taylor, managing director of Stage Entertainment USA. "They rescue each other. It's very uplifting."

The musical stays close to the film, which charted the rise and romance of amateur boxer and debt collector Rocky Balboa, played in Germany by Drew Sarich. No casting has been decided for New York.

In the story, Balboa, nicknamed the Italian Stallion, gets his shot against undefeated heavyweight champion Apollo Creed, played in the film by Carl Weathers. He also woos a love interest, Adrianna "Adrian" Pennino. Stallone wrote the screenplay and it won the best picture Oscar in 1976.

The film made famous the image of Balboa running up the steps of the Philadelphia Museum of Art and the quote "Yo, Adrian!" The German production kept the trumpet-laden funky theme "Gonna Fly Now" and the anthem "Eye of the Tiger," written for "Rocky III." Both will also be in the Broadway version.

The director is Alex Timbers, who directed Broadway's "The Pee-wee Herman Show" and directed and wrote the book for "Bloody Bloody Andrew Jackson." The boxing choreography is being done by Steven Hoggett, who choreographed "American Idiot," ''Peter and the Starcatcher" and "Once."

"This is not boxers doing a kick line," Taylor said. "It's stunning movement representing some of the sparring and the fighting. It's very, very cleverly created."

"Rocky" will be the first new tenant at the Winter Garden Theatre in years. The show that's been there since 2001, "Mamma Mia!," is transferring to another Broadway venue.

The musical will follow two other boxing-related works to appear on Broadway recently: Mike Tyson's one-man show about his life in and out of the ring, and a revival of Clifford Odets' "Golden Boy" about a young man torn between his natural talent as a violinist and the fast money of boxing.

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Online: http://www.ROCKYBROADWAY.com .

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Follow Mark Kennedy on Twitter at http://twitter.com/KennedyTwits

Source: http://news.yahoo.com/musical-rocky-heading-broadway-230232997.html

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Gut bacteria byproduct predicts heart attack and stroke

Apr. 24, 2013 ? A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and death -- even in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesting lecithin. These results demonstrated that the intestinal bacteria are essential for the formation of TMAO.

In the second phase of the study, the researchers measured TMAO levels in a large, independent, clinical cohort -- consisting of more than 4,000 adults undergoing cardiac evaluation at Cleveland Clinic -- over a three-year follow-up period. They found that higher TMAO blood levels were associated with higher future risks of death and nonfatal heart attack or stroke over the ensuing three-year period, independent of other risk factors and blood test results. These results complement those of another recent study of Dr. Hazen's linking gut flora metabolism of a structurally similar nutrient found in animal products, carnitine, to TMAO production and heart attack risk.

"Heart disease remains the No. 1 killer, and while we know how to reduce cholesterol, treat blood pressure, and reduce cardiac risks through diet and other interventions, a substantial residual risk still remains," Dr. Hazen said. "We need to find new pathways to attack heart disease, and these findings strongly suggest that further research into the involvement of gut microbiome in the development of cardiovascular disease could lead to new avenues of prevention and treatment of heart disease."

Dr. Hazen further suggested, "These studies show that measuring blood levels of TMAO could serve as a powerful tool for predicting future cardiovascular risk, even for those without known risk factors. More studies are needed to confirm that TMAO testing, like cholesterol, triglyceride or glucose levels, might help guide physicians in providing individualized nutritional recommendations for preventing cardiovascular disease. Our goal is not to suggest dietary restrictions of entire food groups. Eggs, meat and other animal products are an integral part of most individuals' diets. Our work shows, however, that when digesting these foods, gut flora can generate a chemical mediator, TMAO, that may contribute to cardiovascular disease."

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Story Source:

The above story is reprinted from materials provided by Cleveland Clinic, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. W.H. Wilson Tang, Zeneng Wang, Bruce S. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, Stanley L. Hazen. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 2013; 368 (17): 1575 DOI: 10.1056/NEJMoa1109400

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/D14BpEQC7uQ/130424185211.htm

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Senate votes to move forward on bill taxing Internet sales

By Kim Dixon and Nanette Byrnes

WASHINGTON (Reuters) - A measure to empower U.S. states to require out-of-state retailers to collect online sales tax cleared a legislative hurdle in the Senate on Monday, after earlier winning official backing from President Barack Obama.

Seventy-four senators voted to limit debate and move forward with a final vote on the proposed legislation in the Democratic-controlled Senate, likely on Wednesday.

"You have businesses all around America on Main Streets and shopping malls collecting sales tax on the things that they sell, competing with Internet retailers who do not," said Democratic co-sponsor Senator Richard Durbin.

Supporters of the measure include brick-and-mortar retailers such as Wal-Mart Stores Inc and Best Buy Co Inc and cash-strapped state governments, along with Amazon.com Inc, which hopes to simplify its U.S. state retail tax situation. Opponents include many online merchants, including eBay Inc and Overstock.com Inc.

Prospects for the bipartisan measure are murkier in the Republican-controlled House of Representatives, where some Republicans view it as a tax increase.

Lobbyists on both sides are working to make their case in Congress. Several new wrinkles emerged on Monday, a key one being that the Obama administration for the first time officially backed the measure.

White House spokesman Jay Carney said the bill "will level the playing field for local small business retailers who are undercut every day by out-of-state on-line companies."

Amazon, with its extensive network of distribution centers, already collects tax in nine states, and has agreements with seven more states to start charging in the next year. Amazon has been actively supporting the bill on Capitol Hill.

The bipartisan National Governors Association supports the tax, and in a letter to lawmakers on Monday said the disparate treatment of online and Main Street businesses is "shuttering stores and undermining state budgets."

For its part, eBay's chief executive launched a major lobbying blitz this week, pleading with its millions of users to oppose the effort.

WALL STREET WEIGHS IN

In a twist to the lobbying on the issue that has gone on for years, the Securities Industry and Financial Markets Association came out in opposition to the bill.

Representing big investment banks like Goldman Sachs Group, but also online companies like E*TRADE Financial Corp, SIFMA said the bill could lead to a state-level financial transaction tax and "unexpected" consumer costs.

Eleven EU countries are embracing a federal-level financial transaction tax on trading in stocks, bonds and derivatives. The Obama administration opposes such a tax for the United States.

The idea of imposing a financial transaction tax at the state level in the United States seemed unlikely to Verenda Smith, deputy director of the Federation of Tax Administrators.

She said she was not aware of any states that impose such a tax. "It's hard for a state to even broaden their sales tax to include hairdressers," Smith said. "I don't want to think how hard it would be to broaden to financial transactions."

Under current law, states can only mandate that online merchants with physical stores or affiliates within state borders collect sales tax. Consumers are supposed to pay the tax on their own, but few even know about this.

As a result, online-only retailers often have a pricing edge over bricks-and-mortar retailers in many markets.

Critics say it will create more complications, especially for small businesses, which may have to comply with conflicting state laws and new software.

"The bill has never been about helping Main Street but about helping Big Box stores," said Steve Delbianco, an official with a coalition of e-commerce companies called Netchoice.

The legislation would extend the authority of U.S. states to online sales outside their physical borders, though it would not require them to do so. It would exempt merchants with online annual out-of-state sales of $1 million or less.

"The reason the (banks) are nervous about it is they have managed to successfully argue against their services being taxed because it is so mobile," said Kim Ruben, an economist and director of state issues at the Tax Policy Center, a centrist think tank in Washington.

(Additional reporting by Lisa Lambert and Mark Felsenthal; Editing by Kevin Drawbaugh, Sofina Mirza-Reid, David Gregorio and Eric Walsh)

Source: http://news.yahoo.com/internet-sales-tax-faces-senate-vote-obama-backs-183957410--sector.html

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Spirited 8-year-old among Boston Marathon victims

BOSTON (AP) ? Third-grader Martin Richard had just gotten ice cream and was near the Boston Marathon finish line, eagerly watching for friends to run by. Krystle Campbell was enjoying the race with her best friend, hoping to get a photo of the other woman's boyfriend after he conquered the last mile.

Then the unthinkable struck. The spirited 8-year-old, pictured on Facebook in his classroom holding a sign that read "No more hurting people," was dead, along with the outgoing 29-year-old woman and a graduate student from China ? victims of twin bombs that turned a scene of celebration into chaos.

More than 170 others suffered injuries that included severed limbs, shrapnel wounds, broken bones and head trauma.

Jeff Bauman Jr., a man pictured in an Associated Press photo being rushed from the scene Monday in a wheelchair, lost both legs. Rescuers took the 27-year-old to Boston Medical Center, where doctors found extensive vascular and bone damage.

"Unfortunately my son was just in the wrong place at the wrong time," his father, Jeff Bauman, wrote in a Facebook post.

The younger Bauman, who had been at the race to cheer on his girlfriend, had further surgery because of fluid in his abdomen.

"I just can't explain what's wrong with people today, to do this to people," the father wrote. "I'm really starting to lose faith in our country."

While mourning the dead Tuesday, friends and neighbors tried to focus on positive memories of cherished ones whose deaths still seemed unreal to them.

"I just can't get a handle on it," said Jack Cunningham, a longtime friend of little Martin and his family. "In an instant, life changes."

Cunningham recalled how, as a pint-sized preschooler, the boy had insisted on getting out of his stroller during a 5K race in South Boston. As soon as his mom let him out to run with the rest of the family, Martin took off along the rainy race course.

"He was just having a ball, splashing in every puddle," Cunningham said.

The boy's father, Bill Richard, released a statement thanking friends, family and strangers for their support.

Richard's wife, Denise, and the couple's 6-year-old daughter, Jane, suffered serious injuries in the blasts. Their older son, Henry, wasn't hurt. Two neighbors said Jane lost one of her legs in the attack.

"My dear son, Martin, has died from injuries sustained in the attack on Boston," Richard said. "My wife and daughter are both recovering from serious injuries. We thank our family and friends, those we know and those we have never met, for their thoughts and prayers. I ask that you continue to pray for my family as we remember Martin."

U.S. Rep. Stephen Lynch, a family friend, said Martin and his family were trying to get over the race barriers and into the street after the first blast, when the second bomb struck.

"They were looking in the crowd as the runners were coming to see if they could identify some of their friends when the bomb hit," said Lynch, who has known the Richards for 25 years.

Bill Richard, a runner and cycling enthusiast who did not run the race, had to have several ball bearings removed from his leg, Lynch said.

On Tuesday, a candle burned on the stoop of the family's single-family home in the city's Dorchester section, and the word "Peace" was written in chalk on the front walkway. A child's bicycle helmet lay overturned near the front lawn.

At a nearby park, "Pray for Martin" was written in large block letters on the pavement. Mourners later gathered for a candlelight vigil in the neighborhood.

Next-door neighbor Betty Delorey said Martin loved to climb trees and play sports with his brother and sister and the other children in the neighborhood.

"I can just remember his mother calling him, 'Martin!' if he was doing something wrong," the 80-year-old said. "Just a vivacious little kid."

A photo of the three Richard children on Halloween in 2009 showed a smiling Martin dressed as Woody from the "Toy Story" films, complete with cowboy hat and sheriff's badge. Beside him stood Jane, dressed as the film character Jesse, and Henry, dressed as Harry Potter.

"He had that million-dollar smile and you never knew what was going to come out of him," said Judy Tuttle, a family friend. "Denise is the most spectacular mother that you've ever met and Bill is a pillar of the community. It doesn't get any better than these people."

She recalled having tea recently with Denise Richard, a librarian at the children's elementary school, while Martin did his homework.

"What a gift," Tuttle said of Martin. "To know him was to love him."

Kevin Andrews, headmaster at the Neighborhood House Charter School, said the school community was heartbroken by the loss of the third-grader, whom he called "a bright, energetic young boy who had big dreams and high hopes for his future."

Cardinal Sean O'Malley, head of the Roman Catholic Church in Boston, said a Mass on Tuesday in Israel for victims of the bombing, archdiocese officials said. He also called the pastor of St. Ann parish in Dorchester, where the Richards attend church, to say he was praying for them.

Boston University said one of the victims was a graduate student who was watching the race with friends at the finish line, which is not far from the school. The Chinese Consulate in New York said the victim was a Chinese national, though it did not identify the student. A Hong Kong broadcaster reported the student was a woman from Shenyang studying statistics. The official Chinese news agency Xinhua reported her relatives have requested she not be identified.

In nearby Medford, William Campbell described his daughter, Krystle, as the light of his life, "a very caring, very loving person."

"Daddy's little girl," the 56-year-old said.

Her mother, Patty Campbell, her voice breaking into tears, said the couple was "heartbroken at the death of our daughter."

"She was a wonderful person. Everybody that knew her loved her. ... She had a heart of gold. She was always smiling. You couldn't ask for a better daughter," the mother said. "This doesn't make sense."

Their daughter's best friend, Karen Rand, suffered a severe leg injury in the blasts. "She's very badly hurt. She's all messed up," William Campbell said. "Her leg was all destroyed."

A friend and co-worker at the restaurant where Krystle Campbell was a manager described her as hardworking yet fun-loving, someone who knew how to live life to its fullest.

"We'd go out drinking and she'd work a double the next day," Sheba Parent said. "But she was still career-oriented and focused on her goals."

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Associated Press writers Bob Salsberg, Jay Lindsay and Pat Eaton-Robb in Boston, Katie Zezima in Arlington, Mass., Michelle Smith in Providence, R.I. and Michael Astor in New York contributed to this report.

Source: http://news.yahoo.com/spirited-8-old-among-boston-marathon-victims-002744195--spt.html

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